DOI: 10.36347/sajb.2017.v05i12.002

Pages: 842-846

Infertility affects 1 in 6 couples worldwide and among them males contributes 50% of cases. Male infertility due to genetic factors accounts upto 15%–30% cases. The aim of this study is to determine the frequency and type of chromosomal abnormalities in infertile men. It is a cross sectional academic research environment study. 37 Infertile men with azoospermic (24), oligoazoospermic (6), oligoasthenoteratospermic (7) but otherwise apparently healthy were selected for the study. Peripheral blood lymphocytes were obtained for karyotyping and metaphases were studied by standard GTG banding procedure. The common Chromosomal abnormality of Klinefelter syndrome - 47,XXY was observed in 4 (10.8%) patients and balanced carrier translocation of 46,XY,t(13;19)(q12;q13.4) was observed in 1 patient and 46,XY,t(7;9)(q11.2;p13) in another phenotypically normal patients (5.4%). A normal chromosomal polymorphic variant of 15ps+ was observed in 2 cases and 15pstk+ps+ in one case. This study concluded that the karyotyping is mandatory for the infertile men as diagnostic establishment and suitable genetic counseling, for those seeking assisted reproductive technologies (ART).