DOI: 10.36347/sjams.2017.v05i07.027

Pages: 2630-2636

Cognitive deficit which represent many neuropsychiatric conditions and/or alone as developmental factor for the demand use of nootropic agent to enhance cognitive functions. In current scenario, there is tremendous demand of medicinal plants to explore cognition enhancing potential with fewer side effects. Chronic cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid arteries in rats is associated with behavioral alterations. In Ayurveda, the medicinal properties of Tinospora cordifolia have been attributed to its anti-stress, antioxidant, neuroprotective, adaptogeneic and nootropic properties. The present study evaluated possible role of ethanolic extract of Tinospora cordifolia, in long term cerebral hypoperfusion (a model of cerebrovascular insufficiency and dementia) induced changes in behavioral alterations. Tinospora cordifolia (100 mg/kg, p.o. x 15 days) attenuated the long-term hypoperfusion induced anxiety and listlessness (open field paradigm) along with improvement of learning and memory deficits (Morris water maze testing). The present data report the protective role of Tinospora cordifolia in cerebrovascular insufficiency states and dementia.