DOI: 10.36347/sjams.2020.v08i01.020

Pages: 100-108

Introduction: Pain shares its etymological origin with words punishment and penalty and is the most miserable symptom of disease presentation. Pre-emptive analgesia is used as a treatment that is initiated before surgery in order to prevent the establishment of central sensitization evoked by the incision and inflammatory injuries occurring during surgery and in the early postoperative period. Role of Pregabalin and Flupirtine as pre emptive analgesia has been documented. The present study was undertaken to compare the role of Flupirtine and Pregabalin as pre-emptive analgesic in patients undergoing laparoscopic cholecystectomy because of their documented efficacy, cost effectiveness, pharmacokinetics and minimal side effects or complication. Material and Method: The randomised, double blind, prospective study was carried out in 100 patients scheduled for laparoscopic cholecystectomy and fulfilling the inclusion criteria at Indira Gandhi Institute of Medical Sciences, Patna. Two randomised groups were administered Flupirtine and Pregabalin as pre emptive analgesia and the postoperative outcome were compared and analysed.