DOI: 10.36347/sjams.2018.v06i01.007

Pages: 35-39

The prevalence of obesity among the children has dramatically increased. The serum C-peptide and its correlation with biochemical, clinical and anthropometric parameters were evaluated in 296 children and adolescents(103 control, 96 obese, 97 overweight) of age group 10-17 years. The levels of serum C-peptide were measured by ELISA. Serum C-peptide levels were found to be significantly elevated in both overweight and obese children than controls. Serum C-peptide levels positively correlated with BMI, WHR, serum insulin, HOMA-IR, total cholesterol, triglycerides, LDL-c, systolic and diastolic blood pressure. Fasting glucose levels were found to be negatively correlated with serum C-peptide levels. HDL-c levels were non-significant among the study groups. Elevated serum C-peptide levels have been associated with atherogenic risk factors including increased triglycerides and high blood pressure.