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SAS Journal of Medicine | Volume-4 | Issue-12
Study of Serum Gamma Glutamyl Transferase (GGT) Activity as a Biomarker in Alcoholic Liver Disease
Mukunda Raj Kalouni, Kabi Raj Pandey, Saroj Pokhrel, Sunil Kumar Shah, Vijay K Shah
Published: Dec. 30, 2018 | 76 61
DOI: 10.21276/sasjm.2018.4.12.1
Pages: 207-209
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Abstract
Liver is known to be largest metabolic machinery in the body. Being the largest organ the liver shares with many other abilities to perform its functions with wide reserve capacity. Liver disease reduces the functioning of the liver. Alcohol induced liver diseases is common in this era. Our plan is to use the Serum Gamma Glutamyl Transferase (GGT or γ-GT) as the marker for the diagnosis of alcoholic liver diseases. Serum GGT is a microsomal enzyme, which produces the antioxidant Glutathione and catalyzes the transfer of the gamma-glutamyl moiety of glutathione to various acceptor peptides. In this study we have taken 100 subjects out of those 50 (50%) were healthy individual and 50 (50%) were alcoholic liver disease patients. GGT value of alcoholic liver diseases (140.15 ±79.05) is higher as compare to healthy individual (control) (26.86 ± 10.86) shows statistically highly significant (p=0.001).