DOI: 10.36347/sjams.2018.v06i01.024

Pages: 114-118

The leptin promotes weight loss and can reverse diabetes by improving glucose tolerance by its action on hypothalamus. Present study will be conducted to evaluate the role of leptin in obesity associated maturity onset diabetes. This study was approved by ethical committee of the institution. Study was performed as a randomized controlled trial and with parallel design separately for male and female subjects. The serum glucose, HbA1c, cholesterol, triglycerides, HDL, LDL, insulin, TNF- α, adiponectin and leptin were analyzed by using semi auto analyzer (ERBATM), ELIZA assay kit and chemiluminense assay. Study was done on 200 patients with type 2 diabetic patients to analyze the role of Leptin hormone in obesity induced type 2 diabetes. The type-II diabetes male patients were had significant higher fasting blood glucose (P<0.001), significant high significant HbA1c (P <0.001), non significant high cholesterol (P=0.332), non significant high triglycerides (P = 0.773), significantly higher high-density lipoprotein (P = 0.004), significantly higher low-density lipoprotein (P <0.001), significantly high insulin (P <0.001), significantly high TNF- α (P = <0.001), significant low adiponectin (P<0.001) and non significant low leptin (P<0.001) level were observed as compared to non diabetic subjects. The type-II diabetes female patients were had significant higher fasting blood glucose (P<0.001), significant high significant HbA1c (P <0.001), significant high cholesterol (P=0.016), significant high triglycerides (P = 0.025), non-significantly higher high-density lipoprotein (P = 0.599), significantly higher low-density lipoprotein (P <0.001), significantly high insulin (P = <0.001), significantly high TNF- α (P = <0.001), significant low adiponectin (P<0.001) and significant low leptin (P= 0.003) level were observed as compared to non diabetic subjects.