DOI: 10.36347/sjams.2023.v11i07.026

Pages: 1356-1365

Background: Many studies have focused on male infertility. There is limited evidence about the influence of nutrition on quality of semen. Accumulating evidence suggests that oxidative stress plays an important role in the development of male infertility and recently antioxidants have been tried to treat men with idiopathic infertility. Objective: To evaluate the effectiveness of coenzyme Q-10 treatment in improving sperm motility in men with idiopathic asthenozoospermia. Methods: This randomized controlled study conducted in the Department of Reproductive Endocrinology and Infertility, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from January 2021 to December 2021. Total 74 diagnosed cases of idiopathic asthenozoospermia were selected for medication was included in this study. Eligible man who gave their informed consent was allocated into either Group A (Coenzyme Q-10) or Group B (Placebo) on the basis of computer generated table. Group A received coenzyme Q-10 100 mg two times daily and Group B received placebo for same doses for 12 weeks. Then pretreatment and post treatment semen parameters, including sperm concentration, total motility, progressive motility and morphology was assessed. Results: Post treatment motility (37.8±11.1 vs 26.3±8.8%), progressive motility (30.0±7.9 vs 22.4±7.7) and total motile sperm count (33.5±24.4 vs 21.4±14.3 million) were significantly higher in coenzyme Q-10 group than placebo group (p<0.05). In coenzyme Q-10 group, motility (37.8±11.1 vs 25.2±8.1%), progressive motility (30.0±7.9 vs 22.5±7.0) and total motile sperm count (33.5±24.4 vs 20.0±13.6 million) were significantly increased in post treatment than pretreatment patients (p<0.05), but not found in placebo group. Improvement of sperm motility was significantly higher in coenzyme Q-10 group than placebo group (60.0% vs 5.6%). Conclusion: In conclusion, coenzyme Q10 administration, total motility, progressive motility and total motile sperm count were .....