DOI: 10.36347/sjams.2018.v06i01.041

Pages: 188-191

Diabetes mellitus (DM), is a global metabolic disorder characterized by hyperglycemia, associated with insulin deficiency or resistance, due to endocrinal pancreatic insufficient. The exocrine portion of the pancreas secreted different enzyme involved in nutrients metabolism such as amylase. Endocrinal disturbance observed in diabetes may interfere with the exocrine function of the pancreas. Forty six type 2 Diabetes patients under treatment matched with forty six healthy individuals as control were included in this study. Fasting venous blood samples were collected from each participant and they were analyzed with semi-automated analyzer for fasting blood glucose (FBG), α-amylase (α-AMY) and the lipid profile [triglycerides (TG), total cholesterol (T. CHOL), high density lipoprotein (HDL) and low density lipoprotein (LDL)]. The data were analyzed statistically using SPSS version 16. Significantly low amylase levels were found in the diabetic patients as compared to those in the healthy controls (p value 0.00). Fasting total cholesterol, triglycerides and the LDL were significantly higher in the patients as compared to those in the controls (P = 0.000, 0.011 and 0.000 respectively). The HDL level was found to be lower in the diabetic patients (P 0.000). It was concluded that in Sudanese with type 2 diabetes mellitus, the serum amylase activity was found to be significantly lower than in the healthy controls and negatively correlated with blood glucose level, duration of the disease and lipid profile. This finding reflected an affected endocrine-exocrine axis of the pancreas.