DOI: 10.36347/sjams.2018.v06i01.045

Pages: 215-218

Several studies from different parts of India reported increased TSH in preeclampsia and variable FT3 and FT4 levels. Also, the association between thyroid hormones and severity of preeclampsia are less well studied. This case control study aims to measure thyroid hormones level in non-severe and severe preeclampsia in RIMS, Manipur on 45 diagnosed case of preeclampsia and 46 healthy normotensive pregnant women in the age group of 18-40 years and >20 weeks gestation. Preeclamptic women were grouped as non-severe (n=23) and severe (n=22). Thyroid hormone assay was done by ELISA. Comparison was done by unpaired t-test and correlation by Pearson correlation test. A p-value less than 0.05 were considered significant. The TSH level in severe preeclampsia (6.49±3.24) compared to non-severe preeclampsia (4.46±2.71)(p=0.02) was significantly higher and FT4 (0.80±0.31 vs 1.09±0.53)(p=0.02) was significantly lower in severe preeclampsia. FT3 (1.61±0.82 vs 1.82±0.90) (p=0.43) of severe preeclampsia was non-significantly lower compared to non-severe preeclampsia. The TSH level in preeclamptic patients were significantly higher (5.50 ± 3.12 mIU/L) compared to normotensive pregnancy (2.03 ± 0.78 mIU/L)(p=0.0001). FT4 (0.94 ± 0.45ng/dl, 0.94 ± 0.34 ng/dl) (p=0.99) showed no change in preeclampsia and FT3 (1.71 ± 0.86 pg/ml, 1.73 ± 0.83 pg/ml) (p=0.92) was non-significantly lower in preeclampsia compared to normal pregnancy. This suggests the role of TSH in the pathogenesis and development of severity of preeclampsia. Early detection of thyroid abnormalities may help in better management of the disease in established preeclamptic women.