DOI: 10.36347/sjams.2017.v5i08.003

Pages: 2958-2966

Both benign and malignant lesions of uterine glandular epithelium can have similar presenting feature of abnormal vaginal bleeding. At times, it is difficult to diagnose the nature of the lesion from haematoxylin and eosin stained sections. In such cases morphometry analysis and proliferative studies is expected to differentiate these glandular lesions of endometrium, especially when in dilemma in categorising a lesion benign, premalignant or malignant. This study aims to classify different glandular lesions of endometrium, their prevalence in perimenopausal and postmenopausal women, cellular morphometry in different types of lesions in connection with the clinical profile of the patient, analysis of the expression of proliferative markers like PCNA and Ki67 in these lesions that may have prognostic significance. Morphometric study using nuclear parameters like mean nuclear diameter (MND), mean nuclear area (MNA), mean nuclear perimeter (MNP) and N:C ratio was used to differentiate various benign, borderline endometrial glandular lesions from malignant endometrial glandular lesions in both perimenopausal and postmenopausal age group. In this study we found that morphometric parameters showed significant difference (p<0.05) between benign endometrial glandular lesions and malignant endometrial glandular lesions. In cases where proliferative index was high, age-old Morphometry technique emerged as a more useful tool in differentiating endometrial lesions into benign and malignant.