DOI: 10.36347/sjams.2017.v5i08.010

Pages: 2996-3004

The COX2 gene encodes for the cyclooxygenase-2 enzymes in prostaglandin synthesis. There is a polymorphism (T to C substitution) in the 3’ untranslated region of COX2 gene, providing an increased rate of transcription of COX2 mRNA, which in turn increases enzyme cyclooxygenase-2 synthesis, increases prostaglandin production. 5-HT1A receptor responsiveness is reduced by arachidonic acid metabolite. Activation of serotonin 5-HT1A receptor in the enteric nervous system suppresses gut motility. Genotype analysis was done on 50 patients with IBS and 50 healthy controls by polymerase chain reaction followed by restriction digestion. Patients with C/C COX2 genotype had a risk of IBS with an odds ratio (OR), of 0.84; 95% confidence interval (CI) =0.23-3.08] compared with those with the T/T genotype. The trend of an increasing risk of IBS with an increasing number of C allele was not statistically significant. The C allele of the COX2 gene polymorphism is not associated with increased risk of IBS.