DOI: 10.36347/sjams.2020.v08i01.030

Pages: 155-157

The production of autoantibodies after a hematopoietic stem cell allograft is a fact observed in hematology and often observed during graft versus host disease (GVHD) following an immune disturbance, however studies have shown the possibility of transferring B cells memory from a donor to the recipient and be responsible for autoimmune manifestations similar to that observed in the donor. We present here an extremely rare case of a manifestation of an isolated anti-phospholipid syndrome, 7 years after allograft in a patient whose donor is always asymptomatic. The appearance of autoantibodies was preceded by the appearance of chronic GVHD and the patient posed a management problem in the face of her persistent thrombocytopenia. The distinction between the manifestation of chronic GVHD and adoptive immunity is necessary due to the prognostic and therapeutic differences between these two entities.