DOI: 10.36347/sjams.2017.v5i08.017

Pages: 3042-3049

Thyroid abnormalities are accompanied by changes in intermediary metabolism including alteration in body weight, insulin resistance, lipid profile. Changes in adiponectin have been reported in patients with thyroid dysfunction. But the evidence is controversial. This study was done to evaluate the levels of serum adiponectin levels and lipid fractions in newly diagnosed hypothyroid patients and compare with euthroid controls. A case control study was carried out on patients attending OPD, Department of Medicine RMRI, Bareilly. 100 cases of newly diagnosed hypothyroid cases were taken. 100 age and sex matched euthyroid subjects were taken as a control. All the biochemical parameters (adiponectin, plasma glucose, serum cholesterol, triglyceride, HDL-C, LDL-C, VLDL-C) were evaluated in both the groups. Statistical analysis was done using SPSS 20.0 version. Data was expressed in "mean ±SD". Student t- test and Pearson correlation coefficient was used to find out any significance. The result of this study showed that the level of adiponectin (Hypothyroid; 6.12±2.02 μg/ml; control; 6.59±1.44 μg/ml) decreased marginally (p=0.059) which is statistically insignificant. The levels of total cholesterol, triglyceride, LDL-C, VLDL were significantly increased which is statistically highly significant (p=.000). In our present study the findings suggests that total cholesterol, triglyceride, VLDL and LDL-C levels were significantly increased in hypothyroid patients compared with control group where HDL-C levels were slightly increased. This finding indicates that thyroid dysfunction alters lipids metabolism in our body. These lipid parameters should be evaluated and monitored regularly to predict the future outcome of cardiovascular diseases. The marginal increase of adiponectin level indicates that metabolic changes associated with thyroid disorder are not due to variations in serum alteration of adiponectin though more extensive study with increased sample size may provide more