DOI: 10.36347/sjams.2017.v05i08.043

Pages: 3191-3197

Tumor growth and development involves interaction between tumor cells and extracellular matrix components characterized by cell proliferation, survival, migration into other tissues by invasion or metastasis. Migration of these tumor cells involve degradation of ECM which is facilitated by matrix metalloproteinases (MMPs). Thus MMPs serve useful tool for early diagnosis, prognosis and survival of the disease. Active role of various MMPs in oral squamous cell carcinoma have been evaluated by previous researchers. In this review we depicted various details regarding MMPs as well as their role in oral cancer regarding different aspects and its importance as marker have been highlighted.