DOI: 10.36347/sjams.2017.v05i08.045

Pages: 3204-3208

Cardiovascular diseases are responsible for 25% of DALY lost due to non- communicable diseases in industrialized and developing countries. Life style modification reduces the cholesterol content to a certain extent which can decrease the severity of the presentation of the disease. A persistently high cholesterol levels can almost precipitate a cardiac event. The aim of this study is to estimate Lipid profile and CK-MB and to prove that Total Cholesterol /HDL ratio is a better predictor of atheroscelorosis in Acute Coronary Syndrome. In this study lipid profile and CK-MB was evaluated in fifty subjects who were admitted in the Intensive Coronary Care unit with complaints of chest pain and ECG changes suggestive of Acute Coronary Syndrome and compared with fifty healthy subjects. The statistical analysis was done by student t-test and pearsons correlation in SPSS version 17. The study group showed the mean value of total cholesterol to be 217 .02±34.34 than in the control group which was 182 .33±14.52 and that of HDL cholesterol to be 37.60±3.70 and 42.71±3.48 in control group. The ratio of Total Cholesterol /HDL ratio showed a significant increase than the normal level of <3.5 which is suggested as a clinical goal for coronary artery disease prevention with a sensitivity of 82.5% in relation to individual sensitivity. Hence it can be concluded that though a low level of HDL-C and increase in total cholesterol itself has a strong relation to atherosclerosis the ratio bears considerable importance as a predictive and prognostic indicator for acute coronary syndrome, as HDL cholesterol does not involve the cholesterol associated with LDL-Cholesterol and reverse cholesterol transport.