DOI: 10.36347/sjams.2017.v05i08.056

Pages: 3274-3281

Recent studies have reported that a high serum level of uric acid is strongly associated with impaired renal function and cardio vascular disease. This study aims to find out the role of uric acid in detection of early renal function decline before the onset of microalbuminuria in type 1 Diabetic patient. A total of 130 type 1 Diabetic patients (65 normoalbuminuric & 65microalbuminuric) were recruited in the cross sectional study. Uric acid was measured by enzymatic colorimetric method. Other parameters like blood pressure, body mass index, HbA1c, Fasting Plasma glucose, Plasma lipid profile, serum Creatinine, urine albumin and creatinine ratio were assessed. Estimated Glomerular filtration rate was calculated by CKD-EPI equation. The respective mean uric acid levels in normoalbuminuria & microalbuminuria were 3.92+/-1.59 & 4.99+/-2.48mg/dL(p=0.004). Urinary albumin creatinine ratio in normoalbuminuria was 13.64+/-7.66 and in Microalbuminuria it was 127.98+/-81.23. (p<0.001). In normalbuminuria mean GFR levels were 110.40+/-20.30ml/min and in microalbuminurics it was 100.25+/-27.12ml/min. (p-0.02). eGFR >90ml/min was present in 54.5% of normoalbuminurics & 45.5% of microalbuminurics. eGFR<90ml/min was present in 34.5% of normoalbuminurics and 65.5 % of microalbuminurics. Lower GFR was strongly & independently associated with elevated serum uric acid & increased urinary albumin creatinine ratio. Uric acid was negatively correlated with eGFR (p-<0.001).Serum uric acid in high normal range associated with impaired renal function in patients with type1 diabetes. Therefore it can be used as marker for detecting early renal function decline in patients with type 1 diabetes in Indian clinical setting , where detection rate is lower & complications are higher.