DOI: 10.36347/sjams.2017.v05i08.061

Pages: 3309-3312

Rheumatoid Arthritis is an autoimmune disease affecting 0.5-1% of general population. Among the adipokines secreted by the adipocytes, Leptin act as a new mediator of the inflammatory process and plays a major role in the pathogenesis of Rheumatoid Arthritis. Serum Leptin levels was determined and correlated with the disease activity in the Rheumatoid arthritis patients.60 Rheumatoid arthritis patients diagnosed by American College of Rheumatology (ACR) criteria 2010 aged 25-55years were included in the study. Serum Leptin levels, Erythrocyte sedimentation rate (ESR) were studied and the disease severity calculated and categorised. The mean serum Leptin concentration in RA patients with high disease activity (n=26) was more (51.32+ 33.81ng/mL) than that in moderate activity (n=34) (46.83+30.92ng/mL), though the difference in the mean between the two groups was not statistically significant. As the serum Leptin levels were significantly higher in the RA patients than in the controls it is understood that Leptin plays a pivotal role in the pathogenesis of RA as a proinflammatory cytokine. However no correlation was observed between serum Leptin levels and disease activity of the RA patients.