DOI: 10.36347/sjams.2017.v05i09.004

Pages: 3484-3488

Atherosclerosis is associated with increased inflammatory activity and risk of vascular disease. However, the factors that promote inflammation are not apparently clear. The aim of the present study was to detect homocysteine (Hcy) in urine as a marker for a therothombatic disease among Sudanese patients with Type2 diabetes mellitus with other markers as predictors of cardiovascular disease. A case control study , was conducted included a total of 100 individuals (60 patients and 40 apparently healthy) age was matched in both groups (ranged from 35 to 75 years) 65% male and 35% female, atherogenic lipid profile and HbA1c were measured by Biosystem 350 and Hcy was detected qualitativly by using Spaeth and Barber Modification method Silver – Nitroprusside test. Data analysis was done by using SPSS version 21 and the results revealed that 25 % of the patients had Hcy positive (+ve) while 35 % had Hcy negative (-ve). There was a significant increase of level of total cholesterol, LDLc, HbA1c and significant decreased level of HDLc between study groups. No statistical deffirance was found in levels across gender of patients. The results showed a positive correlation between total cholesterol, LDLc, HDLc and duration while a negative correlation was found with duration and HDLc. Positive correlation was found between BMI and HbA1c, total cholesterol, LDLc, HDLc. In conclusion, Homocysteine is related to CVD risk mildly elevated of homocysteine being an independent risk factor for atherothrombatic disease among Type2 Diabetes Mellitus.