DOI: 10.36347/sjams.2017.v05i09.015

Pages: 3539-3546

To compare the efficacy of Paracetamol and Diclofenac administered intravenously for post-operative analgesia and to assess the safety of intravenous Paracetamol. Pain, a biological phenomenon, is easy to comprehend but difficult to define. Pain inflicted intra operatively continues in post-operative period, and could lead to myocardial ischemia, altered pulmonary functions and cause thromboembolic complications if pain persists. Effective pain management is hence an important component of postsurgical care. After approval from Institutional ethical committee, this study was conducted in 100 ASA I and II patients, posted for tubectomy. Patients were randomly allocated to four groups, 25 patients each, Group I S/I C who were given IV Paracetamol and allowed to breathe spontaneously/whole ventilation was controlled and Group II S/II C who were given IV Diclofenac and allowed to breathe spontaneously/whole ventilation was controlled. The technique of induction and maintenance was similar in all groups. In the post-operative period the following parameters were monitored at time interval 0-4 hours, 5-12 hours, and 24 hours Systolic & Diastolic blood pressure, Pulse rate, VAS, FRS & BRS, Need of rescue analgesic,(Tramadol),Side effects, Patient’s satisfaction.Administration of analgesics Paracetamol and Diclofenac towards end of surgery and repeated at frequent intervals in the post-operative first 24 hours is effective. We also found that in IV Paracetamol groups and in spontaneously breathing groups, hemodynamic variables, VAS, FRS and patient’s satisfaction were better than in Diclofenac and in controlled ventilation group. This study indicates the analgesic effects of newly introduced IV Paracetamol are better than those of the established inj. Diclofenac but larger studies would be needed to firmly conclude the same.