DOI: 10.36347/sjams.2017.v05i10.039

Pages: 3997-4000

To compare the effectiveness and tolerability of misoprostol as a cervical ripening agent in first trimester abortion through sublingual and vaginal administrations of administration before suction evacuation (SE). It was a hospital based comparative study. A total of 100 randomly selected married women were equally divided in two groups for sublingual (S/L) and vaginal and oral 400 mcg of misoprostol single dose administration. The drug was administered 3 hours before SE. Efficacy was assessed on the basis of dilatation achieved, duration of the procedure, intra-operative blood loss. The tolerability was noted on the basis of side effects. Statistical analysis: Mean standard deviation for descriptive analysis and Z test and Chi Square test as test of significance. The cervical dilatation in S/L and vaginal group was comparable. Total duration of the procedure in S/L group was significantly less than vaginal group (p <.0.05). The mean intra-operative blood loss was more in vaginal as compared to the S/L group (p <0.01). Abdominal pain and nausea, episodes of chills were more common with the S/L group than vaginal group. Administration of misoprostol by the sublingual administration is better than vaginal administrations for cervical ripening only disadvantage is that sublingual administration has more side effects.