DOI: 10.36347/sjams.2017.v05i10.043

Pages: 4019-4029

Esophageal cancer is an aggressive malignancy usually associated with a poor prognosis due to loco- regional failure and distal metastasis. The major goal of therapy is restoring and/or maintaining the ability to swallow with minimum morbidity and with reasonable QOL.A prospective Interventional study done at S.G.P.T. Cancer Hospital, M.G.M Medical College Indore with previously untreated, inoperable locally advanced carcinoma of esophagus with palliative intent. A total sixty patient were taken in this study from September 2011 to Sept 2012 and randomly allocate to three ARM Interventional study of three different radiation regimens. The QOL was assessed using the European Organization for Research. We have taken QOL of the patients as an important factor for optimization of treatment schedule to be used for palliation and analyzed the same using QLQ c-30 and QLQ OES -18 questionnaires. Improvement in mean dysphasia grade at 15 days, 1 month and 3 month was nearly equal for all the three arms with maximum improvements in Arm A. The increase in mean global health status score were comparable in Arm A, B, C at one month and three months. The mean physical functioning score also improved in the entire three radiation regimen at one month and three months. While the symptom score decreased after treatment in all the three arms indicating the comparable improvement in symptoms and related complaints after the radiation therapy. Thus any of the three radiation schedules used in Arm A, Arm B and Arm C achieve good palliation with minimal morbidity.