DOI: 10.36347/sjams.2020.v08i01.061

Pages: 320-326

Endometrium is a one of the dynamic tissue of the female genital tract. Carcinoma of endometrium is one of the leading causes of mortality in aged women.The important precursor lesions are hyperplasia with or without atypia, all are mainly influenced by unchecked hormonal imbalance between Estrogen Receptor (ER) and Progesteron Receptor (PR).As the diseases advances from hyperplasia to carcinoma there is change of expression of ER, PR and VEGF leading to changes in treatment protocol. The study was conducted in the Department of Pathology in collaboration with the Department of Obstetrics and Gynaecology, Nilratan Sircar Medical College and Hospital, Kolkata from 1st January 2018 to 30th June 2019. The study included patients attending the Department of Gynaecology and Obstetrics, with clinical and/or radiological suspicion of endometrial pathologies. Total 51 cases were included in our study. The results of ER, PR and VEGF on endometrial carcinoma and its precursor lesions have been discussed below.