DOI: 10.36347/sjmcr.2023.v11i08.007

Pages: 1452-1453

Prolactin is a polypeptide hormone that is synthesized in the anterior pituitary gland and secreted in a pulsatile manner. It plays central role in a variety of reproductive functions and lactation. Prolactin release in humans depends on physiological state and varies in response to different stimuli. Hyperprolactinemia is a common endocrinological disorder; it could be physiological, pathological or idiopathic in origin. In several respects prolactin is unique among anterior pituitary hormones. We report the case of a 25-year-old woman who came to the endocrinology department with galactorrhea. The history revealed spontaneous and provoked galactorrhea, with secondary amenorrhea that had been going on for 05 years and had been neglected by the patient. The questioning did not reveal any particular medication being taken. Our examination revealed induced lactescent galactorrhea and moderate hirsutism with a Ferriman score of 18. Pregnancy was ruled out, Prolactin=148.1 ng/mL (6xN), the rest of the hypophysiogram was unremarkable (no associated hypogonadism). A pituitary magnetic resonance imaging (MRI) revealed no pituitary adenoma or interruption of the pituitary stalk! We adopted the diagnosis of symptomatic non-tumor hyperprolactinemia. Cabergoline was introduced at 0.5 mg per week. The course of the disease was favorable, with a reduction in galactorrhea and normalization of the menstrual cycle.