DOI: 10.36347/sjams.2020.v08i01.054

Pages: 287-292

Background: Most recent trials revealed that insulin resistance could be an only risk factor for cardiovascular diseases in type 2 diabetics. Increased insulin resistance involved in a series of poorly investigated outcome, one of them is ventricular instability, manifested by increase in ventricular repolarization. Current study was undertaken to evaluate the QT Dispersion in type II diabetic subjects as it is cost effective and to assess its correlation with insulin resistance. Methods: 100 diabetics were screened for insulin resistance & QT dispersion & compared with 100 ages & sex matched non diabetics. HOMA -IR for insulin resistance & ECG derived indices QT interval QTi, Corrected QT interval QTc by Bazzet’s formula & QT dispersion QTd were calculated by 12 lead ECG. Insulin resistance calculated from HOMA-IR was correlated with various parameters like abdominal circumference, HBA1c, QTi, QTc, & QTd. Results: QTd was significantly increased in diabetics than nondiabetics. HOMA -IR shows strong positive correlation with abdominal circumference, HBA1c, QT interval & QT dispersion. Conclusion: Raised insulin resistance is associated with increased sympathetic nerve activity which enhances myocardial cell membrane refractoriness and thus leads to prolongation of QT interval. We conclude that QTd as significant prognostic marker for early detection of cardiovascular mortality & can be used as screening tool to prompt further investigation.