DOI: 10.36347/sjams.2017.v05i10.083

Pages: 4227-4233

The objective of the study is to compare the safety and efficacy of equivalent doses of orally and vaginally administrated misoprostol in induction of labour in Primigravida at 37-42 weeks of gestation with vertex presentation with prelabour rupture of membranes. 100 patients divided in oral, 50 cases (mean gestational age group 37 weeks 2 days) and vaginal group, 50 cases (mean gestational age group 38 weeks 3 days) received Tab. 25 µg of misoprostol every 4 hourly either orally or digitally administered in the posterior fornix in the vaginal group. Maximum up-to 6 doses in both groups. Primary outcome of the study was induction delivery interval in oral group 22.90 hours and in vaginal group 17.38 hours. The mean BISHOP score for oral and vaginal group was 4.6 and 5.7 respectively after 8 hours of administration of misoprostol. Vaginal group requires less oxytocin augmentation for delivery. APGAR score at 1 minute in oral group was 7.56 and for vagina group was 7.48. NICU admissions are statistically not significant. The mean induction delivery interval was significantly shorter in vaginal group, the cause of which could be longer duration action, no first pass metabolism and direct action of vaginal misoprostol on uterus on cervix. In oral group failed induction was observed in 6% cases, whereas in vaginal group, no induction failure was observed. Vaginal misoprostol is more effective than oral misoprostol for induction of labour.