DOI: 10.36347/sjams.2017.v05i11.009

Pages: 4340-4349

Uric acid is a risk factor for vascular disease and many experimental and epidemiological data have suggested a possible role for hyperuricemia in inducing endothelial dysfunction, which is involved in diabetes mellitus type 2. It has been associated with various complications like nephropathy, neuropathy, cardiovascular morbidity, retinopathy and other vascular complications etc. The aim of our study was to ascertain the role of serum uric acid in vascular complications of type 2 DM. 1000 patients with type 2 Diabetes Mellitus diagnosed according to ADA criteria from outpatient of diabetic clinic were taken up in the study. These were divided into 2 subgroups depending upon presence or absence of complications as AI (with vascular complications) and AII (without vascular complications). 380 diabetics were without complications, 150 had diabetic neropathy, 70 had diabetic nephropathy, 220 had cardiovascular morbidity, 60 had diabetic retionopathy or cataract while 120 had other complications like gastroparesis, triopathy, frequent UTI, perineal infections, NASH etc. The mean serum uric acid in diabetics without complication (4.43+1.40 mg/dL) was significantly less as compared to mean serum uric acid in those having cardiovascular morbidity due to diabetes (p=.014), those with diabetic retinopathy (p=.004). The mean serum uric acid in those with diabetic neuropathy (p=.027) was significantly lower as compared to those with diabetic retinopathy. The mean serum uric acid value in diabetic nephropathy (p= .005), cardiovascular morbidity due to diabetes (p<.001) and diabetic retinopathy (p<.001) was significantly higher as compared to controls while in those with other complications (p=.031) was significantly lower as compared to those having diabetic retinopathy. The association of uric acid with a particular complication was not clear .Though hyperuricemia is not directly responsible for vascular injury and simply represents a surrogate marker for high levels of damagi