DOI: 10.36347/sjams.2017.v05i11.061

Pages: 4626-4631

Urinary bladder cancer accounts for approximately 7% cancers and 3% of cancer mortality in west, while in India it is the ninth most common cancer. Malignancy of the urinary bladder contributes significantly to the morbidity and thus adding to the burden on the health care system and society. There are very limited studies on urinary bladder tumours, especially from central India. The main objectives of the study was to analyze the histomorphological pattern of urinary bladder tumours especially urothelial tumors of the urinary bladder and their relation with age, sex and correlation of tumor grade with muscle invasion and necrosis. We reviewed all bladder tumour cases reported in the Department of Pathology, BMHRC, Bhopal, M.P., India over a period of 13 years from Jan 2002 to Dec 2014. Total 165 cases of urinary bladder tumours were analyzed. The male to female ratio was 6.5:1 and the average age was 63 years (range: 17 to 90 years). 90% patients presented with painless hematuria. 153 cases (92.7%) were of urothelial carcinomas, 1.2% were squamous cell carcinoma and 6.1% were the other variants including sarcomas, metastatic adenocarcinoma etc. In the Urothelial carcinomas, high grade was observed in 60.7%, whereas low grade was in 33.9% cases. 146 cases (95.4%) were with papillary configuration and 1.4% was carcinoma in situ. Muscle invasion and Necrosis were more common in high grade tumours. Urothelial carcinoma is the predominant urinary bladder cancer, with significant male predominance in central India population. Younger age had low grade urothelial carcinoma. Muscle invasion is noted more in high grade tumours.