DOI: 10.36347/sjams.2018.v06i11.011

Pages: 4213-4216

Leptin is a hormonal product of the ob gene that has important roles in balancing energy regulation, reducing food intake and increasing energy use. Hyperuricemia is a state in which a person uric acid blood level is higher than normal. Obesity is a pathological condition that characterized by the excessive accumulation of body fat. Hyperuricemia associated with obesity. Uric acid is significantly associated with obesity, diabetes mellitus, hypertension and ischemic heart disease. Hyperuricemia in obese people usually happens because uric acid synthesis is increasing while excretion of uric acid by kidneys is decreasing. To determine correlation between leptin and uric acid level in obese adolescents in North Bolaang mongondow regency. This research was used cross sectional method with 52 samples taken from students high schools in North Bolaang Mongondow regency that matched the inclusion and exclusion criteria from this research. The result showed that All subjects had central obesity which consisted of 32% men and 68% women. 28,8% of subjects had hyperuricemia and 15,4% had leptin levels ≥ 40 ng / dL. Correlation test results showed that there is a positive significant correlation between leptin levels and uric acid with ρ = 0.000 and R = 0.334. there was a significant correlation between leptin levels and uric acid.