DOI: 10.36347/sjams.2023.v11i08.007

Pages: 1421-1427

Introduction: Lymphoma, a type of cancer affecting the lymphatic system, requires accurate diagnostic methods for effective treatment. This study aimed to evaluate the validity of Cell Block Histopathology and Fine Needle Aspiration Cytology (FNAC) in the diagnosis of lymphoma. Methods: A total of 30 patients with clinically suspected lymphoproliferative disorder were included in the study. Both Cell Block Histopathology and FNAC were used to diagnose lymphoma in these patients. The results were then compared with the final diagnosis based on histopathology, immunochemistry, and clinical follow-up, which was considered the gold standard. Result: The study included 30 patients with clinically suspected lymphoproliferative disorder. The Cell Block Histopathology method diagnosed 12 patients (40%) as lymphoma positive, 11 patients (36.67%) as lymphoma negative, and 7 cases (23.33%) were inconclusive. The Fine Needle Aspiration Cytology (FNAC) method diagnosed 13 patients (43.33%) as lymphoma positive, 12 patients (40%) as lymphoma negative, and 5 cases (16.67%) were inconclusive.When compared with the final diagnosis based on histopathology, immunochemistry, and clinical follow-up, the sensitivity, specificity, and accuracy of Cell Block Histopathology were 91.67%, 90.91%, and 93.33% respectively. The positive predictive value (PPV) and negative predictive value (NPV) were both 91.67%. The FNAC method demonstrated a sensitivity, specificity, and accuracy of 92.31%, 91.67%, and 93.33% respectively. The PPV and NPV were 92.31% and 91.67% respectively. Conclusion: This study concludes that both Cell Block Histopathology and FNAC are valid and effective diagnostic tools for lymphoma. They can be used independently or in conjunction with one another to enhance diagnostic accuracy. The findings contribute to the growing body of evidence supporting the use of these methods in lymphoma diagnosis.