DOI: 10.36347/sjams.2018.v06i02.050

Pages: 724-729

Propofol, an intravenous (IV) anesthetic is associated with pain on injection with incidence ranging from 28% to 90% in adults. The aim of present study is to know the anti-nociceptive effect of dexmedetomidine infusion with that of control (Normal saline) infusion immediately prior to propofol injection in alleviating Propofol injection pain (PIP). The present study was a randomized controlled study where in following the approval of the hospital's ethics Committee, 60 consenting adult patients were randomly divided into two groups A and B (n = 30) to receive 20 ml of normal saline as control and 0.5 μg/kg of dexmedetomidine diluted in 20 ml of normal saline respectively. The propofol injection pain was assessed according to the Mc Cririck and Hunter scale. The 27(90%) patients in control group expressed pain compared to 9(30%) patients in Dexmedetomidine Group. In the present study, participants receiving dexmedetomidine 6(20%) patients were determined to be in Grade 1 and 2(6.67%) participants were in grade 2 followed by 1(3.33%) patients were determined to be in Grade 3. There is no significant difference between heart rate, Mean Arterial Pressures and haemodynamic side effects in both groups. Pre-treatment with0.5 µg/kg of dexmedetomidine is effective in alleviating incidence and severity of propofol induced pain, did not cause significant hemodynamic adverse side effects.