DOI: 10.36347/sjams.2018.v06i02.054

Pages: 742-747

HIV infection has compounded the obstetric problems. There is conflicting data on the effect of HIV infection as well as antiretroviral therapy (ART) on pregnancy outcome. To assess maternal and neonatal outcome in HIV positive pregnant women whether or not on antiretroviral therapy (ART).2. To study HIV prevalence of pregnant women delivering in tertiary care center and 3. To study pregnancy outcome in HIV infected women as compared to uninfected women. This case control was carried out in tertiary care teaching institute in central India for period of three years which included both retrospective and prospective data. We studied the pregnancy outcome of HIV positive patients (Group-A) and compared it with healthy uninfected controls (Group-B). Further analysis of HIV positive patients was done by subdividing it into two groups as on ART (Group-A1) and not on ART (Group-A2). A detailed clinical examination was carried out in each patient as per proforma at the time of admission and relevant information was recorded. Patients monitored throughout the pregnancy and delivered according to hospital protocols. Maternal and neonatal outcomes were studied in details. Statistical analysis: For descriptive statistics mean, standard deviation, proportions and percentages were used. Unpaired t test and Fisher exact test were used as test of significane. Total 108 patients were found to be HIV infected and controls were 222 non-infected patients. Prevalence of HIV infected patients delivering in our institute was 0.35%.Preterm deliveries were observed significantly more in infected patients (14.8%) than uninfected controls (7.6%) (p=0.042). Whereas no significant difference was observed whether on ART or not (p=0.834).ICCU admissions were observed significantly more in infected patients (2.7%) than uninfected controls (0%) (p=0.034). Whereas no significant difference was observed whether on ART or not (p=1.000).Mean birth weight was 2.38±0.56 kg in cases and 2.59±0.4