DOI: 10.36347/sjams.2018.v06i03.002

Pages: 807-810

To study the impaired glucose tolerance and serum ferritin level in transfusiondependent β-thalassemic children. A prospective and hospital based study.Setting: Kamala Raja Hospital, G.R.Medical College, Gwalior. Known case of beta Thalassemia major children being regularly transfused in Department of Pediatrics, Kamla Raja Hospital, Gwalior. This study was done on 60 children between 3-17 years of age with β thalassemia. Major information regarding name, age, sex, height, body weight, age at the first blood transfusion, frequency of blood transfusion per year, age at the start of iron-chelation therapy, compliance with chelation therapy, H/O Diabetes mellitus and history of previous splenectomy was taken. For each patient glucose tolerance test was performed. Significant variation was found (p value<0.001) in children with impaired glucose tolerance compared to normal glucose tolerance with respect to age, age of first blood transfusion, age of starting chelation therapy. Patients with impaired glucose tolerance had a mean transfusions of 137.58±20.15 times while those with normal glucose tolerance had 58.85±39.80 times of transfusions.(p.value<0.001) Conclusion: Most of patients with impaired glucose tolerance in present study had received more then 100 blood transfusion with mean age of 13.0 years indicating that abnormal glucose homeostasis begin after 10 year of age.