DOI: 10.36347/sjams.2020.v08i02.017

Pages: 445-447

Glutathione is considered as a major molecule that plays an essential role in the antioxidant defense system. The mechanism of chemotherapeutic agents are act based on oxidative stress to kill the cancer cell, so the antioxidant activity of glutathione is thought to be interfering with chemotherapeutic action.The aim of the recent study is Estimation of Plasma Reduced Glutathione among Sudanese Females with Breast Cancer Undergoing Chemotherapy .The current study was conducted on 100 Sudanese females with Breast Cancer who attended the Institute of Nuclear Medicine – Madani – SUDAN between August to October / 2018. ELISA 96 well plates (OD 412 nm) and quantiChrom Glutathione assay kit were used to measure the level of reduced glutathione in Plasma. The outcome of the recent study, the level of plasma reduced glutathione in patients was significantly higher than control (MEAN 92.03±46.6; 13.87±9.27 respectively; P-value 0.001). Our finding suggests that the status of reduced glutathione levels might be play a role as a prognostic factor for poor response of chemotherapy in Sudanese female with Breast Cancer.