DOI: 10.36347/sjams.2018.v06i03.038

Pages: 998-1006

The purpose of this study to compare the efficacy and safety 2% rebamipide, 0.18% sodium hyaluronate and 1% carboxy methyl cellulose eye drops in treatment of mild to moderate dry eye disease. Patients with mild to moderate dry eye were enrolled in this randomized prospective study. They were divided into 3 following groups, patients in rebamipide group treated with 2% rebamipide 4 times daily, in SH group treated with 0.18% sodium hyaluronate 6 times daily and CMC group treated with 1% carboxy methyl cellulose 6 times daily. Fluorescein corneal staining, tear film breakup time, schirmer’s test, OSDI score and adverse reactions were assessed at baseline, 2weeks, 4weeks and 12 weeks after treatment initiation was done in this study. Sixty patients were allocated randomly in three groups, 20 patients in the rebamipide group, 20 patients in the CMC group, and 20 patients in the SH group. Three groups of drugs showed significant improvement in FCS, TBUT, schirmer’s test and OSDI score at 2week, 4 week and 12 week of initiation of treatment. However, rebamipide group was showed statistically significant differences in the above indices than the CMC and SH groups. There were no significant adverse reactions observed during follow up. 2% rebamipide, 0.18% sodium hyaluronate, and 1% CMC were effective in the treatment of mild to moderate dry eye. But 2% rebamipide was more efficacious than 0.18% sodium hyaluronate and 1% carboxy methyl cellulose.