DOI: 10.36347/sjams.2018.v06i03.040

Pages: 1015-1020

Guillain-Barre Syndrome is the commonest cause of acquired demyelinating disorders affecting the peripheral nervous system in any part of the world. It is a spectrum of illness of diverse etiology with a common pathological process. It is a non-seasonal illness affecting persons of all age groups. The severity of Guillain-Barre Syndrome varies from mild weakness to total paralysis and respiratory failure, sometimes leading to death. Predominantly study conducted at Govt. District Hospital, Ratlam & also covered rural population of Ujjain & Indore & its surroundings. It offers medical management to all economic status of people, all religions and all age groups. It is more ideal to conduct a study in this institution. The diagnosis of Guillain-Barre Syndrome is made predominantly by clinical examination and aided by investigations like cerebrospinal fluid analysis and electrodiagnostic studies. 80% of Guillain-Barre Syndrome patients recovered smoothly without going for complications. 30% of Guillain-Barre Syndrome patients developed respiratory muscle weakness of varying severity. 40% of patients showed features of autonomic disturbance of varying severity. 2 patients had features suggestive of ocular muscle involvement and in 1 patient feature of incordinationwas present. Prognostic outcome in our study is somewhat poor with increasing age. Prognostic outcome is poor when there is co-existing illness like diabetes mellitus or ischemic heart disease. Cerebrospinal fluid analysis in patients the Guillain-Barre Syndrome who had increased protein correlated with severe demyelination in electrodiagnostic studies and delayed recovery. Prognosis in patients the Guillain-Barre Syndrome linearly varies with severity of electrodiagnostic studies. H-reflex was invariably absent in all those patients included in the study. F-response was absent in 90% of patients in lower limbs and 70% of patients in upper limbs. Reduction in motor nerve conduction velo