DOI: 10.36347/sjams.2018.v06i03.064

Pages: 1131-1135

The significance and role of thyroid gland for maintenance of adequate growth and health is well known. According to data available from various studies on thyroid disease it has been estimated that about 42 million people in India were suffer from thyroid diseases. Zinc is a trace element and an essential nutrient in humans. It play important role including T3 binding to its nuclear receptors and is needed for the formation and action of TRH. The present study has been undertaken to determine the serum zinc level in hypothyroidism patients and to study the correlation between the levels of zinc with TSH levels. This study has been carried out in the department of Biochemistry in RMCH, Bareilly, with 60 known cases of hypothyroidism and 60 apparently healthy controls. The zinc levels were estimated by colorimetric method and TSH by sandwich ELISA method. Our study shows that mean ± SD of serum zinc was significantly lower in cases than in control. Correlation between serum Zn and TSH is inversely proportional. Thus routine screening for serum Zn should be carried out in person with thyroid dysfunction to assess the therapeutic improvement.