DOI: 10.36347/sjams.2018.v06i03.075

Pages: 1187-1191

Diazepam and bromazepam though are restricted drugs are commonly used especially in this part of the world; it is a known fact that some medications has negative effect on lipid profile. The aim of this study is to investigate the effect of short term administration these drugs on albino wistar rats. This study investigated the in-vivo effect of short term administration of diazepam (DZ) and bromazepam (BZ) at 0.0046 mg/100 g bwt (1), 0.0036 mg/100 g bwt (2), 0.0026 mg/100 g bwt (3) and 0.0016 mg/100 g bwt (4) concentrations on serum lipid profile of albino wistar rats. The parameters that were investigated are: total cholesterol, triglyceride, high density lipoprotein (HDL) and low density lipoprotein (LDL). Data obtained were subjected to statistical calculation using SPSS version 18. Mean values (M) ± SD were calculated and One-Way ANOVA test was performed, significance level was calculated at 95 % confidence level (P ˂ 0.05). Serum HDL, serum LDL, serum total cholesterol, and serum triglyceride were reduced by both drugs throughout the duration of study in a dose-dependent manner. The reduction was significant (P < 0.05) for total cholesterol and triglyceride. Comparing the reducing/increasing effect between the two drugs at similar dosage showed no significant difference. Short term administration of diazepam and bromazepam at these low dosages does not affect negatively total cholesterol, triglyceride, HDL and LDL concentrations.