DOI: 10.36347/sjams.2020.v08i02.028

Pages: 495-498

Prostate Specific Antigen is considered as an established tumor marker in diagnosis, staging and evaluation of prostatic adenocarcinoma. However the utility of serum PSA alone in the interpretation of prostate carcinoma remains controversial and uncertain since it lacks sensitivity and specificity. Gleason score and grade grouping determines the biological behavior and acts as important parameters in staging and prognosis of prostatic carcinoma. Hence in our study we aimed to correlate the serum PSA levels with gleason score and grade group in the diagnosis and evaluation of prostatic adenocarcinoma in Transrectal ultrasound guided prostatic biopsies. The study was conducted in a tertiary care hospital, South India over a period of one year (2018-2019). We evaluated a total of 36 TRUS guided prostatic core biopsies. We found that the percentage of positivity for adenocarcinoma is about 50% of the total cases. The mean PSA value was 3.83(±5.43) in benign cases and 80.39(±99.07) in malignant cases. Serum PSA levels were higher in biopsies with high gleason scores and grade. The diagnostic efficacy of serum PSA level was significant with an area under the ROC curve of 0.972 which showed high sensitivity and specificity.