DOI: 10.36347/sasjs.2018.v04i05.006

Pages: 104-106

Hip and knee arthritis can cause persistent pain and disability for patients and in this case, total hip arthroplasty (THA) and total knee arthroplasty (TKA) can be performed as it is an effective surgery for those patients. However, the main concern about the surgery is bleeding. Tranexamic acid (TXA) is an anti-fibrinolytic synthetic agent synthetically block plasminogen activation to plasmin and hence stabilization of blood clotting. TXA showed efficacy in reducing blood loss and it widely has several clinical usage including orthopedic field. To discuss the role of intravenous and topical TXA in THA and TKA. Scientific websites were used to search for articles related to this review; several keywords were focusing on the subject to get more researches. There were more than 20 articles included in the review. There was controversial to determine the best route to administrate TXA and which is superior as the high quality trials are lacking and there were differences between different study. However, using TXA either intravenously or topical showed efficacy and safety in both THA and TKA. Blood loss as well as blood transfusion was significantly reduced in both procedures with less adverse effects by using TXA.