DOI: 10.36347/sasjm.2023.v09i08.014

Pages: 880-882

Diabetes Insipidus is a heterogeneous clinical syndrome of disturbance in water balance, characterized by polyuria, polydipsia and failure to thrive. The clinical presentation varies with age of onset and underlying etiology. There is no clear consensus among pediatric endocrinologists on managing neonates with diabetes insipidus. Diagnosis is based on the presence of high plasma osmolality and low urinary osmolality with significant water diuresis. Water deprivation test is useful in establishing a diagnosis of diabetes insipidus and helps differentiating between nephrogenic diabetes insipidus and central diabetes insipidus. However, is difficult to be performed during neonatal age. Fluid management is the most safe approach to treat. Desmopressin, although is the drug of choice for CDI therapy, however during neonatal period, fluid management with or without thiazide is preferred. In this survey, we analyzed the responses of 35 pediatric endocrinologists regarding neonatal diabetes insipidus management, and their recommendations were reported.