DOI: 10.36347/sjavs.2015.v02i01.013

Pages: 67-78

Interleukin-33 (IL-33) is an IL-1-like cytokine ligand for the IL-1 receptor-related protein ST2. Allergic rhinitis (AR) is one of the most common allergic inflammatory diseases. Globally, more than 600 million persons have AR. AR is divided into categories: seasonal and peren-nial. The way genomic histories drove the evolution of the IL-33 family in mammalian species was described; IL-33 genes were searched in nine mammalian such as Bos taurus, Sus scrofa, Oryctolagus cuniculus,and the Ovis aries and then through phylogenetic analysis. Microsynteny analysis was made based on genomic segments containing the IL-33 genes. Some pairs turned out to conform with syntenic genome regions, while others corresponded to those that were inverted, expanded, or contracted after the divergence of mammalians. Besides, we dated their duplications by Ks analysis and demonstrated that all the blocks were formed after the split; we observed Ka/Ks ratios representing strong purifying selections in the four mammalian species which might have been followed by gene loss and rearrangement.