DOI: 10.36347/sjmcr.2023.v11i08.031

Pages: 1554-1556

Immunoglobulin M multiple myeloma (IgM MM) is a rare variant of multiple myeloma (MM) accounting for less than 1% of all MM cases. In contrast, the majority of patients with MM demonstrate monoclonal IgG (52%) or IgA (21%) in their serum and urine. The clinical presentation of IgM MM can overlap with that of Waldenstrom's macroglobulinemia (WM), making it challenging to establish an accurate differential diagnosis. In this report, we present a case of IgM multiple myeloma in a patient who exhibited symptomatic anemia, extensive lymphadenopathy, and cytogenetic abnormalities commonly associated with this subtype. We provide a detailed account of the diagnostic evaluation, treatment approach, and subsequent response observed in this patient.