DOI: 10.36347/sjams.2018.v06i04.009

Pages: 1422-1427

The aim of this study is to compare the efficacy of two different anesthesia induction approach i.e Inj Thiopentone sodium and Inj. Etomidate in maintaining hemodynamic stability during induction and following endotracheal intubation in elective surgery. After obtaining Ethical committee clearance, 90 patients aged 15 to 60 years of either sex or ASA physical status I or II scheduled for elective surgery under general anaesthesia were taken for study. Written and informed consent was taken from the patients. This was conducted at Kamineni Academy of Medical sciences and research centre, Hyderabad. The patients were randomly placed into two groups. Group T induced with Inj.Thiopentone sodium (5 mg/kg) intravenous, Group II with Inj. Etomidate (0.3 mg/kg) intravenously. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP) and oxygen saturation (SPO2) were noted at different time interval. Heart rate in all study groups decreases after induction and it was more in group T compared to group E and after intubation HR increases in two groups but this increase is greater in group E than groupT. MAP among all three groups decreases after induction and it was more in group T than group E and Significant increase in MAP was seen at 1 min after intubation in all three groups but this increase was not sustained and returned to baseline in group II. The etomidate has better hemodynamic stability than thiopentone sodium at 1 min after intubation and was equally stable at other points of time.