DOI: 10.36347/sjams.2018.v06i04.020

Pages: 1486-1489

The aim of this original study was to evaluate the pre-emptive effect of Pregabalin on postoperative pain in patients scheduled for surgery under general anaesthesia. Post-operative ward and OT Department of anesthesia J. A. Hospital, G. R. Medical College, Gwalior MP. This was double-blind, randomised, prospective clinical study. Total 60 patients of ASA grade I and II posted for elective surgeries under general anaesthesia were randomised into 2 groups (Group A and Group B of 30 patients each). One and half hour before surgery, the drug selected for the study was given blindly with a sip of water. Group A received 300mg Pregabalin capsule; Group B received identical placebo capsule. Pain (Visual analogue score) and side effects assessment were performed immediately and then at 15mins. 30mins 45mins. 60mins, 90mins, 120mins, and 180mins, postoperatively. The mean (±SD) of VAS score was 5.86 ± 0.34 in Group B and 4.96 ± 1.03 in Group A. VAS score was significantly lower in Group A as compared to Group B. With oral pregabalin time required for rescue analgesia is delayed as compared to control group. The mean (±SD) TRA-1 was 38.40±24.61 in Group B and 58.69±25.21 in Group A. Pregabalin also causes sedation. No significant difference was observed among the two groups regarding side effects during the study period. This clinical study demonstrated that pre-emptive oral Pregabalin 300 mg significantly decreases the severity of pain postoperatively as compared to placebo in patients posted for surgery under general anaesthesia. Time for analgesic requirement is more with oral Pregabalin. The VAS score was lower in Pregabalin group. Oral Pregabalin produces higher degree of sedation than the placebo group.