DOI: 10.36347/sjams.2018.v06i04.028

Pages: 1519-1522

Tuberculosis (TB) burden in India is very high accounting for nearly 20% of the global incidence. India also ranks second in holding multi drug resistant (MDR)-TB cases. To identify rifampicin resistance cases in sputum positive pulmonary tuberculosis patients by history, clinic radiological tools, sputum examination and performing cartridge based nucleic acid amplification test (CB-NAAT) on suspected MDR cases. Hundred sputum- positive tuberculosis patients were studied. Three sputum samples were collected from each patient. The specimens collected, packed at the collection centers and sent to the linked CB-NAAT laboratory. Bacteriological examination was performed. Mean age of study population was 37.5±14.03 years. Males (79%) outnumbered the females. Most of them were farmers (49%). All the patients had productive cough followed by fever (79%) and breathlessness (67%). Diabetes mellitus (6.3% in male and 9.5% in female) was the most common co-morbid condition. Twenty eight percent of the cases were resistant to rifampicin. Maximum (71.4%) of the study subjects resistant to rifampicin were males compared to female (28.6%) (p=0.246).Sputum AFB resistant to rifampicin and sputum AFB sensitive to rifampicin was insignificant in default cases (32.1% vs. 23.6%, p>0.05), but significant in relapse (46.4% vs. 20.8%, p=0.010) and new cases (25.5% vs. 55.6, p=0.002) respectively. About one fourth of our patients were resistant to rifampicin and males were more affected. Diabetes mellitus was the common co-morbid condition. Significant difference was observed in relapse and new cases between rifampicin resistance and sensitivity.