DOI: 10.36347/sjams.2020.v08i02.065

Pages: 723-729

Non-alcoholic fatty liver disease (NAFLD) is one of the major risk factors in hepatic insulin resistance (IR). Though the association of NAFLD with type 2 diabetes (T2DM) is well studied, the prevalence of NAFLD and its association with IR in non-diabetic, first degree relatives (FDR) of T2DM is not explored. Therefore, the present study is aimed to estimate the prevalence of NAFLD and its association with IR in FDR of T2DM individuals. It is a cross-sectional study involving 165 FDR subjects who are non-diabetic were screened for NAFLD using abdominal ultrasound scanning, clinical assessment and biochemical parameters. The study found 22% prevalence of NAFLD and 43% prevalence of IR in the study population. Further, comparison was made between NAFLD and non NAFLD subgroups. The prevalence of IR, obesity, central obesity and hypertension were significantly high (P<0.01) in NAFLD subjects when compared to that of non NAFLD. Prevalence of elevated SGPT, cholesterol and triglyceride were also significantly high among NAFLD subjects. The results showed strong association of NAFLD with IR with odds ratio >13 in FDR individuals. Overall, the study indicated high prevalence of NAFLD and its association with insulin resistance among first degree relatives of diabetics even in normoglycemic status.