DOI: 10.36347/sjams.2018.v06i04.093

Pages: 1833-1837

Diabetes mellitus, a global problem, affects the functions of the liver characterized by altered metabolism and glucose homeostasis. The relationship of increase in various liver enzymes in type 2 diabetes mellitus, causing hepatocytes dysfunction is not well established. The present study was carried out to focus on various liver enzymes like aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl trans peptidase (GGT) and to find out correlation, if any, between type 2 diabetes mellitus and liver functions and its effect over the liver. The present study also focuses whether there is any relationship between the severities of Type 2 diabetes mellitus on liver functions. The present study was a case-control study and was carried out on 40 diagnosed cases of type 2 diabetes mellitus with age group of 30-80 years and 15 healthy controls who were age and sex matched. Serum was collected from blood sample of all the 55 subjects and was sent for biochemical investigations. In the present study, mean Fasting blood sugar (FBS) and Post-prandial blood sugar (PPBS) of type 2 diabetic subjects was found to be 195.45 ± 53.39 & 283.27 ± 74.57 as compared to controls 78.66 ± 10.30 & 118.13 ± 10.78. It was observed that liver enzymes (AST, ALT, ALP & GGT) were not significantly raised in mild diabetic subjects (p > 0.05) as compared to controls, whereas, these enzymes were significantly increased in moderate and severe diabetic subjects as compared to controls. Liver dysfunction has significant relationship with the severity of type 2 diabetes mellitus.