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Scholars Journal of Applied Medical Sciences | Volume-8 | Issue-03
Acute Myeloid Leukemia “Cup-Like”: About A Case and Litterature Review
H. Yahyaoui, A. Jahdaoui, A. Raissi, E. Boufrioua, M. Oujidi, M. Ait Ameur, M. Chakour
Published: March 7, 2020 | 159 137
DOI: 10.36347/sjams.2020.v08i03.003
Pages: 783-785
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Abstract
Cup‑like acute myeloid leukemia (CL AML) is a rare form of acute myeloid leukemia, but its frequency is probably underestimated because it is a poorly understood and little described entity. Characterized by a particular biological profile: hyperleukocytosis, massive blastosis, disseminated intravenous coagulation, nuclei marked by a clear nuclear invagination, relatively stereotyped immunophenotype: CD34- / HLA-DR- / MPO + / CD117 + / CD13 +. Often associated with a normal karyotype, CL AML cytology is highly predictive of molecular abnormalities affecting NPM1 and FLT3.