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Scholars Journal of Applied Medical Sciences | Volume-8 | Issue-03
Lipoprotein (A) in Acute Myocardial Infarction among Middle Aged Population with Coronary Angiographic Correlation- An Observational Study
Dr. Arun Ranganathan, Dr. P. Deepa
Published: March 13, 2020 | 160 111
DOI: 10.36347/sjams.2020.v08i03.015
Pages: 877-880
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Abstract
Acute myocardial infarction (AMI) is one of the leading causes of mortality among coronary artery disease (CAD). Lipoprotein (a) Lp(a) may aggravate atherosclerosis by pro-thrombotic, pro-inflammatory and pro-atherogenic effects This observational study was conducted in 206 acute Myocardial Infarction patients of age less than 45 years of both sexes who underwent coronary angiogram in Department of Cardiology,Government Stanley Medical College for 6 months after getting informed consent. This study was performed to determine the levels of Lp(a) in acute myocardial infarction. Coronary angiogram was performed for all acute myocardial infarction patient and serum Lp(a) and LDL levels were analysed. In our study, the difference in Lp(a) values between obstructive CAD & non – obstructive CAD were not statistically significant (p value 0.863). Eight patients who had positive family history had high Lp(a) levels. Important findings in this study includes that the Lp(a) levels were independent of high LDL( Low density Lipoprotein) values and the level of Lp(a)is higher in women(67%) than in men (33%). With regard to management, this group of patients need a targeted approach apart from regular statins and they may have to be treated with extended release Niacin