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Scholars Journal of Applied Medical Sciences | Volume-8 | Issue-03
The Role of Urinary N-Acetyl-Beta- D-Glucosaminidase to Determine the Activity of Lupus Nephritis
Dr. A.S.M Julfekar Helal, Dr. Md. Hafizur Rahman
Published: March 18, 2020 | 92 46
DOI: 10.36347/sjams.2020.v08i03.020
Pages: 902-905
Objective: In this study our main goal is to evaluate the role of urinary N-acetyl-beta- D-glucosaminidase to determine the activity of lupus nephritis. Method: This cross-sectional prospective observational type of study was conducted among 60 Diagnosed lupus nephritis patients (active and inactive) at Department of Nephrology, Dhaka Medical College Hospital, Dhaka. From January 2017 to December 2017. The informed written consent was taken from each patient. Results: during the study, 62(mIU/ml) is the best uNAG cutoff value for determination of lupus nephritis activity.Among 29 active lupus nephritis cases raised uNAG was found in 28 cases and among 31 inactive lupus nephritis cases raised uNAG was found in 2 cases.uNAG in determination of lupus nephritis activity showed accuracy, sensitivity, specificity, PPV and NPV were 0.950, 0.966, 0.935, 0.933 and 0.967 respectively. Conclusion: From our study we can conclude that, uNAG is a useful biomarker for determination of lupus nephritis activity. Further large-scale study should be carried out for reaching optimal goal.